Briefing Archive

June 28, 2026 Corticosteroids Significantly Increase Risk of Mania and Depression in Meta-Analysis 5 articles June 27, 2026 Centanafadine Expands ADHD Indication With Comorbid Anxiety Efficacy 5 articles June 26, 2026 Amisulpride Boosts Ventral Striatum Perfusion in MDD, Shedding Light on Dopaminergic Anhedonia Mechanisms 7 articles June 25, 2026 FDA NDA Watch: Otsuka’s Centanafadine Gains Momentum With Positive Phase 3b ADHD Data 9 articles June 24, 2026 Biomarker-Guided Varenicline Doubles Abstinence in 'Sign-Tracker' Smokers 8 articles June 23, 2026 Definium’s Phase 3 LSD Trial Hits Primary Endpoint in Major Depression 14 articles June 22, 2026 Benzos After Trauma Don’t Raise PTSD Risk, Challenging Blanket Guidelines Against Early Prescribing 12 articles June 21, 2026 PDE4 Inhibitor Roflumilast Boosts Memory Networks in Schizophrenia 10 articles June 20, 2026 Clozapine’s Superior Efficacy May Stem From Muscarinic Agonism, Not Just Dopamine Blockade 11 articles June 19, 2026 Centanafadine Proven Effective for ADHD in Adults and Children 11 articles June 18, 2026 Meta-Analysis Shows Magnetic Seizure Therapy Matches ECT for Depression With Better Cognitive Safety 16 articles June 17, 2026 FDA Approves First Drug Specifically for Agitation Associated With Dementia Due to Alzheimer Disease 13 articles June 16, 2026 Spironolactone Repurposed for Schizophrenia: RCT Targets NRG1-ERBB4 Pathway 12 articles June 15, 2026 Subcutaneous Risperidone Maintains Therapeutic Levels for 56 Days in Phase 1 Trial 9 articles June 14, 2026 Single-Dose Psilocybin Yields Months of Relief from Chronic Suicidal Ideation 6 articles June 13, 2026 Lumateperone Linked to Lower Risk for Schizophrenia Relapse 8 articles June 12, 2026 Pramipexole Significantly Reduces Anhedonia in Mood Disorders: RCT Evidence for Dopamine Agonist Augmentation 7 articles June 11, 2026 FDA Rejects Cingulate’s Once-Daily ADHD Drug CTx-1301 in Complete Response Letter 6 articles June 10, 2026 Lurasidone-Induced Mania in Bipolar I: A Case Report Highlighting Switch Risks Despite Atypical Antipsychotic Profile 9 articles June 09, 2026 Adjunctive N-acetylcysteine accelerates symptom reduction in OCD patients on high-dose sertraline 6 articles June 08, 2026 Clinical refresher: Flumazenil reverses benzodiazepines during ECT to mitigate cognitive side effects 20 articles June 07, 2026 Clinical refresher: N-acetylcysteine reduces heavy drinking days in comorbid bipolar-AUD via dorsal anterior cingulate glutamate modulation 20 articles June 06, 2026 Academic Detailing Boosts AUD Medication Prescribing in VA Primary Care 5 articles June 05, 2026 Luvesilocin Enters Phase 2 for Postpartum Depression as Novel Psychedelic Prodrug 24 articles June 04, 2026 Autobahn Reports Positive Phase 2 Data for Elunetirom, a Novel Thyroid Receptor Agonist, in Bipolar Depression 42 articles June 03, 2026 FDA Rejects Cingulate’s Timed-Release Dexmethylphenidate for ADHD Over Manufacturing Deficiencies 37 articles June 02, 2026 Japanese Consensus 2025: Symptom-Specific Antipsychotic Recommendations for Schizophrenia 22 articles June 01, 2026 Zonisamide Linked to First Reported Case of Homicidal Ideation 7 articles

May 31, 2026 rTMS to Orbitofrontal Cortex Improves Schizophrenia Symptoms by Modulating Brain Network Connectivity 7 articles May 30, 2026 Centanafadine Phase 3 Post Hoc Data Reveals Gains in Executive Function and Emotional Dysregulation for Adult ADHD 12 articles May 29, 2026 Psilocybin Shows Promise in Recurrent Depression Beyond Refractory Cases 16 articles May 28, 2026 AAFP: Combination Antidepressant Therapy Outperforms Monotherapy for Acute Severe and Nonresponding Depression 24 articles May 27, 2026 VA Launches MDMA Trial for Veterans’ PTSD 32 articles May 26, 2026 ASCP Consensus: When and How to Deprescribe Stimulants in ADHD Care 25 articles May 25, 2026 ADHD Stimulants Linked to Reduced Semen Volume in Men 7 articles May 24, 2026 Pre-emptive Pharmacogenetic Testing Lowers Antidepressant Discontinuation Rates 7 articles May 23, 2026 EU Accepts Teva’s Long-Acting Injectable Olanzapine for Schizophrenia 16 articles May 22, 2026 Intranasal Clozapine Cuts Dose by 97% in Preclinical Study 20 articles May 21, 2026 Tocilizumab Induces Remission in Treatment-Resistant Depression 23 articles May 20, 2026 Mirtazapine Repurposed for Methamphetamine Use Disorder: New Evidence for an Antidepressant’s Off-Label Potential 25 articles May 19, 2026 Low-Dose Buprenorphine Sustains Ketamine’s Antisuicidal Effects in Major Depression 27 articles May 18, 2026 GLP-1 Agonists Emerge as Off-Label Treatment for Alcohol Use Disorder 19 articles May 17, 2026 Psilocybin’s 3-Month Durability: Single Dose Sustains Rapid Antidepressant Remission 15 articles May 16, 2026 ADHD Dosing Sweet Spots: Network Meta-Analysis Reveals Minimal Benefit Beyond Optimal Limits 29 articles May 15, 2026 Clozapine’s Gut-Lung Link: New Mechanism Ties GI Hypomotility to Respiratory Infection Risk 41 articles May 14, 2026 Semaglutide Boosts Motivation in Depression, Offering New Off-Label Hope for Anhedonia 39 articles May 13, 2026 Psilocybin Shows Early Promise for Chronic Suicidal Ideation in Open-Label Trial 26 articles May 12, 2026 RDX-002 Targets Antipsychotic-Induced Weight Gain: New Data Presented at APA 28 articles May 11, 2026 Meta-Analysis Confirms Methylphenidate Reduces Growth Z-Scores in Pediatric ADHD, Urging Individualized Monitoring 20 articles May 10, 2026 Lumateperone Gains Schizophrenia Relapse Prevention Indication, Cementing Role of Atypical Antipsychotics in Maintenance Therapy 20 articles May 09, 2026 FDA Approves Auvelity for Alzheimer’s Agitation, Expanding Dextromethorphan/Bupropion Beyond Depression 34 articles May 08, 2026 Lithium Altered Brain Electrical Activity Linked to Impulsive Suicide Risk 38 articles May 07, 2026 Genotype-Guided SSRI Prescribing Boosts Depression Remission, Validating Pharmacogenomics in Clinical Practice 31 articles May 06, 2026 Clozapine-Associated Pulmonary Embolism: Case Highlights Risk of False-Negative D-Dimer 26 articles May 05, 2026 Lumateperone Ranks Highest Among Adjunctive MDD Therapies in First Network Meta-Analysis 20 articles May 04, 2026 Escitalopram Boosts Cognitive Flexibility by Reducing Belief Stickiness in OCD 12 articles May 03, 2026 New Study Reveals Ketamine’s Opioid Receptor Mechanism for Rapid Antidepressant Effects 14 articles May 02, 2026 This week in psychopharmacology: The rise of non-antipsychotic agents for Alzheimer’s agitation 20 articles May 01, 2026 FDA Approves First Non-Antipsychotic for Alzheimer’s Agitation: Auvelity Offers New Option 52 articles

April 30, 2026 FDA Halts Newron’s Evenamide Schizophrenia Trial After Patient Death 44 articles April 29, 2026 FDA Fast-Tracks Psilocybin and Methylone for Mental Health, Signaling Shift in Psychedelic Psychopharmacology 34 articles April 28, 2026 Psilocybin Beats Nicotine Patches for Smoking Cessation in Novel Trial 30 articles April 27, 2026 FDA Approves Caplyta for Schizophrenia Relapse Prevention, Citing 63% Risk Reduction 25 articles April 26, 2026 HS-10380 Phase 3 Data: Novel Antipsychotic Challenges Aripiprazole in Acute Schizophrenia 38 articles April 25, 2026 Valproic Acid Cuts Clozapine Levels by Half; UGT Polymorphisms Demand Personalized Dosing 55 articles April 24, 2026 AXS-05 Shows Promise for Alzheimer Agitation Ahead of PDUFA; Novel Psychostimulant Safe in Psychosis History 65 articles April 23, 2026 FDA Ends Clozapine REMS; New Guidelines Address Prolactin Monitoring and Bipolar Relapse Risks 69 articles April 22, 2026 Trump's Psychedelic Order Accelerates Psilocybin Pathways While Xanomeline/Trospium Enters Schizophrenia Care 69 articles April 21, 2026 FDA-authorized Psilocybin PEX010 study shows promise; Ketamine fails in anesthesia trials 121 articles April 20, 2026 France Approves IV Ketamine for Suicidal Crisis; Novel α7nAChR Astrocyte Mechanism Explains Cognitive Trial Failures 103 articles April 19, 2026 Lithium Weight Gain: New Strategies to Improve Long-Term Adherence 78 articles April 18, 2026 Lilly's Tirzepatide Risks Greater Muscle Loss vs Semaglutide; Cochrane Challenges Alzheimer's Drugs 123 articles April 17, 2026 Lilly's obesity drug advances despite FDA liver concerns as RNA CAR-Ts enter autoimmunity trials 169 articles April 16, 2026 FDA demands safety data on Lilly's Foundayo amid breakthroughs in Alzheimer's detection and AI cardiac screening 174 articles April 15, 2026 FDA advances gene therapy safety and approves first FSGS drug; Revolution's pancreatic cancer therapy nearly doubles survival 174 articles April 14, 2026 Pancreatic cancer drug doubles survival time; FDA rejects Replimune's melanoma therapy 142 articles April 13, 2026 Pancreatic Cancer Drug Doubles Survival; Parkinson's Meds Metabolized by Gut Bacteria 63 articles April 12, 2026 FDA rejects Replimune cancer therapy; new biomarkers advance Alzheimer's, Parkinson's, and schizophrenia detection 64 articles April 11, 2026 Obesity drug risks rise as AI links loneliness to diabetes and trauma alters children's sensory processing 131 articles April 10, 2026 Genetics and Gut Microbes Drive New Breakthroughs in Obesity, Alzheimer's, and ALS Treatment 156 articles April 09, 2026 Novo launches high-dose Wegovy as FDA seeks new ad powers; mental health and neurology breakthroughs advance 150 articles April 08, 2026 Tepezza delivery shift, HIV pill under $5, and brain switches for eating and Alzheimer's dominate psychiatric breakthroughs 143 articles April 07, 2026 Neurocrine's $2.9B Soleno Acquisition and New Insights into Psychiatric MAID Eligibility 107 articles April 06, 2026 Trump's drug tariffs threaten psychiatric care; new insights reveal brain circuits for pain, memory, and reality perception. 137 articles April 05, 2026 Trump's drug tariffs threaten care; new research reveals brain circuits for pain, memory, and psychosis. 99 articles April 04, 2026 Lilly's oral GLP-1 approved alongside critical insights on EBV-MS links, SPT-neuropathy risks, and schizophrenia treatment evolution 121 articles April 02, 2026 FDA warns of Tavneos liver deaths; SCOT upholds conversion therapy; New Alzheimer's and antipsychotic breakthroughs emerge 183 articles