This article argues for prioritizing empiric treatment with lorazepam or ECT in suspected catatonia cases to mitigate high mortality risks, addressing barriers like underdiagnosis and clinician hesitation regarding benzodiazepine dosing.

This study demonstrates that a blood-based proteomic algorithm can accurately predict cognitive status and treatment response to Vitamin E in adults with Down syndrome, supporting the use of precision diagnostics for Alzheimer's disease in this population.

This article outlines a depth-oriented group psychotherapy protocol for treating moral injury in military veterans using relational psychoanalytic theory.

Elevated soluble CD27 in cerebrospinal fluid serves as a sensitive biomarker for identifying severe psychiatric patients with comorbid autoimmune diseases and active neuroinflammation, suggesting that psychiatric symptoms may precede somatic manifestations of autoimmunity.

The Parent-report Nationwide Quality of Life Scale (P-NQLS) is a valid, reliable 7-item instrument providing age- and sex-specific normative data to distinguish quality of life deficits from symptom severity in children aged 6-18.

This cohort study of 430 pediatric patients on antipsychotics found that while ECG abnormalities were common (45.5%), clinically significant QTc prolongation was rare (5.6%) and transient, supporting a risk-based rather than universal monitoring strategy.

This Phase 3 clinical trial investigates whether perioperative dexmedetomidine reduces post-procedure grief and PTSD symptoms following second-trimester abortion, representing a potential new pharmacological application for an existing sedative.

This clinical trial investigates functional changes in the frontotemporal cortex during ECT and MST for MDD using fNIRS, a methodology relevant to understanding treatment mechanisms but currently not yet recruiting.

This article describes a clinical trial comparing venous and arterial tourniquets for seizure monitoring during electroconvulsive therapy (ECT), a procedure used to treat major depressive disorder, bipolar disorder, and schizophrenia.

This is a clinical trial comparing venous versus arterial tourniquets for seizure monitoring during ECT, a critical safety parameter in electroconvulsive therapy.

This study elucidates the molecular mechanism by which SHANK3-mediated phase separation regulates postsynaptic density remodeling and AMPA receptor trafficking during long-term potentiation, with specific relevance to autism spectrum disorders.

A subcortical visual pathway from the superior colliculus to hypothalamic oxytocin neurons mediates social visual awareness and drives the onset of parental behaviors in mice.

The ABCD-BIDS Community Collection release 3.1.0 provides a robust, harmonized resource of over 24,000 processed diffusion MRI datasets demonstrating that intracellular volume fraction and return-to-origin probability are highly sensitive markers for adolescent white matter maturation across diverse scanning environments.

Hippocampal activity distinguishes between reactive escape and anticipatory avoidance during foraging threats by encoding location-specific representations prior to behavioral divergence.

Engineers have developed flexible artificial neurons capable of generating lifelike electrical signals to successfully communicate with and activate living brain cells in vivo.

This systematic review elucidates the dopaminergic mechanisms by which antipsychotics impair pancreatic beta-cell insulin secretion, providing mechanistic evidence to explain and manage antipsychotic-induced glucose dysregulation.

A systematic review indicates that probiotic interventions may induce neurobiological changes associated with improved psychiatric symptoms, though further research is needed to confirm efficacy and clarify mechanisms.

Astrocytic α7nAChRs, not neuronal ones, are the critical mediators of pro-cognitive effects via D-serine/NMDAR signaling, explaining the failure of prior clinical trials targeting this receptor.

TREM2 deficiency exerts opposing, region-specific effects on cerebral amyloid angiopathy pathology, reducing cortical amyloid while exacerbating cerebellar accumulation and neuroinflammation.

Frontal traumatic brain injury induces chronic nucleus accumbens remodeling that reduces the salience of reward-predictive cues, thereby contributing to impaired decision-making and psychiatric symptoms post-injury.

A randomized controlled trial demonstrates that internet-delivered psychodynamic therapy and cognitive-behavioral therapy yield comparable 12-month outcomes and costs for adolescent depression, offering viable non-pharmacologic treatment alternatives.

The Signal Generating (SiGn) phantom is a novel, open-source 3D-printed tool that enables end-to-end validation of fMRI preprocessing pipelines by providing dynamic, anatomically realistic ground-truth activation data previously unattainable with static phantoms.

A multicenter cohort study demonstrates that implementing smart digital screening tools for high-risk psychiatric patients significantly reduces emergency department visits by prioritizing rapid outpatient evaluation.

This article describes a clinical trial evaluating internet-based cognitive behavioral therapy for mild-to-moderate anxiety and depression in Singapore.

This article describes a clinical trial evaluating whether early brainwave biomarkers can optimize personalized transcranial magnetic stimulation protocols for treatment-resistant depression.

President Trump's executive order directs federal agencies to expedite psychedelic treatments as breakthrough drugs and expand access via right-to-try legislation, signaling a potential shift in regulatory pathways for serious mental illness.

France becomes the first country to approve intravenous ketamine for severe suicidal crisis, while scientists investigate its antidepressant efficacy under anesthesia.

A Class II recall has been issued by the FDA for one lot of Viatris 3 mg extended-release Xanax (alprazolam) due to failed dissolution specifications that may result in inconsistent drug release and reduced efficacy.

A new statement provides clinical recommendations for safely deprescribing psychotropic medications in long-term care settings to reduce inappropriate prescribing.

A clinical trial is recruiting to evaluate the effects of Dextromethorphan-Bupropion on striatal activity in adults with Major Depressive Disorder.

This podcast discusses the HAMLETT study's finding that psychiatrist-specific factors significantly influence antipsychotic outcomes in first-episode psychosis, alongside key evidence on early tapering strategies and dopamine supersensitivity.

This podcast provides an evidence-based overview of Dissociative Identity Disorder (DID) etiology and treatment but does not report new pharmacological data or prescribing guidelines.

This podcast details the assessment of violence-associated delusions in forensic settings and highlights clozapine as a key pharmacological intervention for reducing violence risk alongside cognitive behavioral therapy.

This large-scale meta-analysis evaluates the efficacy and clinical interpretability of interventions for negative symptoms in schizophrenia, providing critical evidence to guide antipsychotic selection and adjunctive treatment strategies.

Biovac nets $108M finance package to build Africa’s first fully integrated vaccine plant

Biogen bullish on America with Durham Bulls team up

Bayer falls short in bid to block J&J’s survival claims in prostate cancer clash

Brain Cancer Awareness: The Importance of Molecular Testing for Patients with Rare Brain Tumors

AI simulates real-world HCP feedback on pharma content